The weird sound when running audio interface

As back to Hackintosh, I use Yamaha AG06 as audio interface. Here is something weird, when I listen to music from YouTube, then open "about this MAC", the noise just happen for a while, but sometimes worse than that, the music will stop. I don't know what's going on. This situation won't happen when I use the internal audio device. Anyone has idea about this?

Author: @GY-guy