macOS Mojave 10.14.5 (recently updated): Everything becomes unresponsive after about an hour of use

I recently updated my Hackintosh from 10.14.1 to 10.14.5 (including Clover, though I only replaced the EFI files and kexts with the updated ones, no changes to config). After the update, I noticed that everything would stop responding after a bit of use and would require me to hard shutdown my PC. I am still able to move my mouse around and switch between open applications, but unable to start any new ones or use anything on Finder (can't right click stuff on desktop, open folder, etc). While it is unresponsive, I did notice that Activity Monitor shows that IO is frozen. I also can't SSH because, while it will let me log in, it won't actually load. I have no idea what would be causing this or how to fix this. Any ideas?

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Specs:

• CPU: Intel Core i7 6700K
• GPU: AMD RX 580
• Motherboard: MSI Z170A Gaming Pro Carbon
• Storage: Samsung 850 EVO (dual booted w/ Windows and macOS), Seagate Barracuda (NTFS), Seagate Firecuda (NTFS)