Will it work on an AMD system?

I want to install Sierra or High Sierra, and I have 2 questions. 1: How do I get Macintosh boot media AND run it? 2: Will it run on an OEM AMD system? Specs are as follows: Athlon II x4 640 Geforce 9800 GT Some weird Toshiba Wi-Fi card 2x 160GB Seagate's 1x 500GB Seagate HP Pavilion P6727C Motherboard